Evidence reviews for diagnostic test accuracy of IgE in children (2025)

Abdel-Aziz, M.I., Brinkman, P., Vijverberg, S.J.H.et al. (2020) eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy. Journal of Allergy and Clinical Immunology146(5): 1045–1055 [PubMed: 32531371]

- Index test not relevant to this review protocol

FeNO used as index test

Agarwal, Ritesh, Dua, Devika, Choudhary, Hansrajet al. (2017) Role of Aspergillus fumigatus-specific IgG in diagnosis and monitoring treatment response in allergic bronchopulmonary aspergillosis. Mycoses60(1): 33–39 [PubMed: 27523578]

- Population not relevant to this review protocol

Already diagnosed with asthma

Agodokpessi, G., Sagbo, G., Bigot, C.et al. (2019) Mite sensitization in children followed for respiratory allergy in a tropical African environment in Cotonou, Benin. Revue des Maladies Respiratoires36(2): 135–141 [PubMed: 30686558]- Study not reported in EnglishAhlstedt, S, Eriksson, N, Lindgren, Set al. (1974) Specific IgE determination by RAST compared with skin and provocation tests in allergy diagnosis with birch pollen, timothy pollen and dog epithelium allergens. Clinical allergy4(2): 131–40 [PubMed: 4858363]

- Population not relevant to this review protocol

Already diagnosed with asthma/allergic rhinitis

Ahn, J.Y. and Choi, B.S. (2018) Clinical evaluation of specific immunoglobulin e in sputum in pediatric patients. Pediatric, Allergy, Immunology, and Pulmonology31(2): 73–77

- Data not reported in an extractable format or a format that can be analysed

Data not reported for false positives and negatives

Ahumada, V, Garcia, E, Dennis, Ret al. (2015) IgE responses to Ascaris and mite tropomyosins are risk factors for asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology45(7): 1189–200 [PubMed: 25702830]

- Population not relevant to this review protocol

Not presenting with respiratory symptoms

al-Dusari, S N; Somorin, A O; Zaman, A U (1997) IgE antibodies to mites in Saudi Arabia. Allergy52(2): 234–5 [PubMed: 9105535]

- Population not relevant to this review protocol

Average age >16 years

Arikoglu, T.; Batmaz, S.B.; Kuyucu, S. (2018) Allergen sensitization patterns in atopic children in mersin province of Turkey. Asim, Allerji, Immunoloji16(3): 157–164

- Index test not relevant to this review protocol

IgE measured but not reported

Armentia, A., Martin-Armentia, S., Pineda, F.et al. (2020) Allergic hypersensitivity to garlic and onion in children and adults. Allergologia et Immunopathologia48(3): 232–236 [PubMed: 31477394]

- Population not relevant to this review protocol

Average age >16 years

Bernardini, Roberto, Pucci, Neri, Azzari, Chiaraet al. (2008) Sensitivity and specificity of different skin prick tests with latex extracts in pediatric patients with suspected natural rubber latex allergy-a cohort study. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology19(4): 315–8 [PubMed: 18266828]

- Condition not relevant to this review protocol

Study aiming to diagnose latex allergy

Boersma, N.A., Meijneke, R.W.H., Kelder, J.C.et al. (2017) Sensitization predicts asthma development among wheezing toddlers in secondary healthcare. Pediatric Pulmonology52(6): 729–736 [PubMed: 28076664]

- Population not relevant to this review protocol

Inclusion criteria <5 years

Bolat, E., Arikoglu, T., Sungur, M.A.et al. (2017) Prevalence and risk factors for wheezing and allergic diseases in preschool children: A perspective from the Mediterranean coast of Turkey. Allergologia et Immunopathologia45(4): 362–368 [PubMed: 28410872]

- Population not relevant to this review protocol

Average age <5 years

Brand, P.L.P., Brohet, R.M., Schwantje, O.et al. (2022) Association between allergen component sensitisation and clinical allergic disease in children. Allergologia et Immunopathologia50(2): 131–141 [PubMed: 35257556]- Data not reported in an extractable format or a format that can be analysedBurbach, G J, Heinzerling, L M, Edenharter, Get al. (2009) GA(2)LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe. Allergy64(10): 1507–1515 [PubMed: 19772516]

- Population not relevant to this review protocol

Average age >16 years

Businco, L and Cantani, A (1990) Food allergy in children: diagnosis and treatment with sodium cromoglycate. Allergologia et immunopathologia18(6): 339–48 [PubMed: 1708197]- Review article but not a systematic reviewBuslau, A., Voss, S., Herrmann, E.et al. (2014) Can we predict allergen-induced asthma in patients with allergic rhinitis?. Clinical and Experimental Allergy44(12): 1494–1502 [PubMed: 25270425]

- Population not relevant to this review protocol

Average age >16 years

Byeon, J.H., Ri, S., Amarsaikhan, O.et al. (2017) Association between sensitization to mold and impaired pulmonary function in children with asthma. Allergy, Asthma and Immunology Research9(6): 509–516 [PMC free article: PMC5603479] [PubMed: 28913990]

- Population not relevant to this review protocol

Already diagnosed with asthma

Can, C.; Altinel, N.; Hatipoglu, S. (2021) Aeroallergen sensitisation patterns of children aged 5 years and younger with asthma and/or allergic rhinitis in Istanbul. Archives de Pediatrie28(1): 7–11 [PubMed: 33342684]

- Population not relevant to this review protocol

Average age <5 years

Cantani, A, Ferrara, M, Barbieri, Cet al. (1990) Evaluation of new test (Phadiatop) for the screening of respiratory allergic disorders in children. Annals of allergy64(2pt1): 158–61 [PubMed: 2306017]

- Condition not relevant to this review protocol

Study aims to diagnose atopy (rhinitis, asthma and rhino conjunctivitis) but doesn’t differentiate between conditions

Cassimos, Dimitrios C, Tsalkidis, Aggelos, Tripsianis, Gregorios Aet al. (2008) Asthma, lung function and sensitization in school children with a history of bronchiolitis. Pediatrics international : official journal of the Japan Pediatric Society50(1): 51–6 [PubMed: 18279205]

- Data not reported in an extractable format or a format that can be analysed

No information on false positives and negatives

Caudri, Daan, Wijga, Alet H, Hoekstra, Maarten Oet al. (2010) Prediction of asthma in symptomatic preschool children using exhaled nitric oxide, Rint and specific IgE. Thorax65(9): 801–7 [PubMed: 20805175]

- Population not relevant to this review protocol

Average age <5 years

Chang, Y.-C., Lee, T.-J., Huang, C.-C.et al. (2021) The role of phadiatop tests and total immunoglobulin E levels in screening aeroallergens: A hospital-based cohort study. Journal of Asthma and Allergy14: 135–140 [PMC free article: PMC7898199] [PubMed: 33628036]

- Condition not relevant to this review protocol

Aiming to diagnose allergic rhinitis

Chauveau, A., Dalphin, M.-L., Mauny, F.et al. (2017) Skin prick tests and specific IgE in 10-year-old children: Agreement and association with allergic diseases. Allergy: European Journal of Allergy and Clinical Immunology72(9): 1365–1373 [PubMed: 28235151]

- Population not relevant to this review protocol

Birth cohort, not presenting with respiratory symptoms

Chen, X.; Li, Y.; Zeng, M.Y. (2014) Diagnostic values of combination of free running asthma screening test and total serum allergen IgE level in children with asthma. Chinese Medical Journal127(5): 873–877 [PubMed: 24571880]

- Population not relevant to this review protocol

Not presenting with respiratory symptoms

Choi, Inseon S, Koh, Youngil I, Koh, Jeom-seoket al. (2005) Sensitivity of the skin prick test and specificity of the serum-specific IgE test for airway responsiveness to house dust mites in asthma. The Journal of asthma : official journal of the Association for the Care of Asthma42(3): 197–202 [PubMed: 15962877]

- Population not relevant to this review protocol

Average age >16 years

Contreras, JPaola, Ly, NgocP, Gold, Diane Ret al. (2003) Allergen-induced cytokine production, atopic disease, IgE, and wheeze in children. The Journal of allergy and clinical immunology112(6): 1072–7 [PubMed: 14657861]

- Population not relevant to this review protocol

Birth cohort, not presenting with respiratory symptoms

Cristina Diaz, M., Lavrut, A.J., Slullitel, P.et al. (2022) Usefulness of analytic tests for the diagnosis of cow’s milk protein allergy. Archivos Argentinos de Pediatria120(1): 21–29 [PubMed: 35068116]

- Population not relevant to this review protocol

Average age <5 years

Cudowska, B and Kaczmarski, M (2004) Diagnostic value of birch recombinant allergens (rBet v 1, profilin rBet v 2) in children with pollen-related food allergy. Roczniki Akademii Medycznej w Bialymstoku (1995) 49: 111–5 [PubMed: 15631325]- Data not reported in an extractable format or a format that can be analysedCuttitta, Giuseppina, Cibella, Fabio, La Grutta, Stefaniaet al. (2003) Non-specific bronchial hyper-responsiveness in children with allergic rhinitis: relationship with the atopic status. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology14(6): 458–63 [PubMed: 14675473]

- Population not relevant to this review protocol

Already diagnosed with allergic rhinitis

Cvitanovic, Slavica, Znaor, Ljubo, Kanceljak-Macan, Bozicaet al. (2007) Allergic rhinitis and asthma in southern Croatia: impact of sensitization to Ambrosia elatior. Croatian medical journal48(1): 68–75 [PMC free article: PMC2080503] [PubMed: 17309141]

- Population not relevant to this review protocol

Already diagnosed with allergic rhinitis/asthma

de Sousa, R.B., Medeiros, D., Sarinho, E.et al. (2016) Risk factors for recurrent wheezing in infants: a case-control study. Revista de saude publica50: 15 [PMC free article: PMC4904490] [PubMed: 27143615]

- Population not relevant to this review protocol

Average age <5 years

Dezfouli, S.G., Mothes-Luksch, N., Jensen, A.N.et al. (2020) Linking cross-reactivity clusters of food and respiratory allergens in PAMD@ to asthma and duration of allergy. World Allergy Organization Journal13(12): 100483 [PMC free article: PMC7691607] [PubMed: 33294115]

- Population not relevant to this review protocol

Average age >17 years

Diaz-Vazquez, Carlos, Torregrosa-Bertet, Maria Jose, Carvajal-Uruena, Ignacioet al. (2009) Accuracy of ImmunoCAP Rapid in the diagnosis of allergic sensitization in children between 1 and 14 years with recurrent wheezing: the IReNE study. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology20(6): 601–9 [PubMed: 19220775]

- Reference standard not relevant to this review protocol

IgE used as reference standard for diagnosis of sensitization

Dibek Misirlioglu, E., Gungor, S., Nacaroglu, H.T.et al. (2014) An evaluation of characteristics and concomitant allergic diseases in children with atopic dermatitis. Asim, Allerji, Immunoloji12(2): 97–103

- Condition not relevant to this review protocol

Study aiming to diagnose atopic dermatitis

Dogru, M. (2016) Investigation of asthma comorbidity in children with different severities of allergic rhinitis. American Journal of Rhinology and Allergy30(3): 186–189 [PubMed: 27216348]

- Study design not relevant to this review protocol

No reference standard used

Eidukaite, A., Gorbikova, E., Miskinyte, M.et al. (2023) Molecular sensitization patterns to cat and dog allergens in Lithuanian children population. World Allergy Organization Journal16(10): 100827 [PMC free article: PMC10562746] [PubMed: 37822703]

- Reference standard not relevant to this review protocol

No reference standard

Eigenmann, Philippe A, Kuenzli, Markus, D’Apuzzo, Vincenzoet al. (2009) The ImmunoCAP Rapid Wheeze/Rhinitis Child test is useful in the initial allergy diagnosis of children with respiratory symptoms. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology20(8): 772–9 [PubMed: 19549098]

- Population not relevant to this review protocol

Already diagnosed with asthma/allergic rhinitis

Eysink, Petra E D, ter Riet, Gerben, Aalberse, Rob Cet al. (2005) Accuracy of specific IgE in the prediction of asthma: development of a scoring formula for general practice. The British journal of general practice : the journal of the Royal College of General Practitioners55(511): 125–31 [PMC free article: PMC1463187] [PubMed: 15720934]

- Population not relevant to this review protocol

Average age <5 years

Fiocchi, A., Besana, R., Ryden, A.-C.et al. (2004) Differential diagnosis of IgE-mediated allergy in young children with wheezing or eczema symptoms using a single blood test. Annals of Allergy, Asthma and Immunology93(4): 328–333 [PubMed: 15521367]

- Population not relevant to this review protocol

Inclusion criteria <5 years

Freidhoff, L R and Marsh, D G (1993) Relationship among asthma, serum IgE levels and skin test sensitivity to inhaled allergens. International archives of allergy and immunology100(4): 355–61 [PubMed: 8481654]

- Population not relevant to this review protocol

Inclusion criteria >16 years

Fuiano, N., Diddi, G., Delvecchio, M.et al. (2015) Diagnostic performance of the atopy patch test with inhalant allergens. Journal of Investigational Allergology and Clinical Immunology25(1): 34–39 [PubMed: 25898692]

- Data not reported in an extractable format or a format that can be analysed

No false positive/negative data

Gleeson, M., Cripps, A.W., Hensley, M.J.et al. (1996) A clinical evaluation in children of the Pharmacia ImmunoCAP system for inhalant allergens. Clinical and Experimental Allergy26(6): 697–702 [PubMed: 8809427]

- Population not relevant to this review protocol

General population, not specifically people with suspected asthma

Gonzalez-Mancebo, E., Dominguez-Ortega, J., Blanco-Bermejo, S.et al. (2017) Comparison of two diagnostic techniques, skin-prick test and component resolved diagnosis in the follow-up of a cohort of paediatric patients with pollinosis. Multicentre pilot study in a highly exposed allergenic area. Allergologia et Immunopathologia45(2): 121–126 [PubMed: 27477032]

- Population not relevant to this review protocol

Already diagnosed with asthma

Hoffmann-Petersen, B., Host, A., Toksvig Larsen, K.et al. (2013) Prevalence of IgE sensitization in Danish children with suspected asthma. Pediatric Allergy and Immunology24(8): 727–733 [PubMed: 24192403]

- Population not relevant to this review protocol

30% of participants using ICS with no washout prior to testing

Hofman, J.; Tobolczyk, J.; Puchnarewicz, A. (1997) Specific IgE against bacterial antigens in children with bronchospastic symptoms. International Review of Allergology and Clinical Immunology3(3): 149–152

- Data not reported in an extractable format or a format that can be analysed

No data on negative test results

Hou, Xiangqing, Luo, Wenting, Gan, Huiet al. (2022) Childhood blood eosinophils and symptoms of allergic disorders: a cross-sectional study in Southern China. Annals of medicine54(1): 2929–2940 [PMC free article: PMC9586638] [PubMed: 36259652]

- Data not reported in an extractable format or a format that can be analysed

No diagnostic accuracy data reported

Jang, Yoon Young and Ahn, Ji Young (2020) Evaluation of Fractional Exhaled Nitric Oxide in Pediatric Asthma and Allergic Rhinitis. Children (Basel, Switzerland)8(1) [PMC free article: PMC7822451] [PubMed: 33374635]

- Index test not relevant to this review protocol

FeNO used as index test

Khakzad, M.R., Mirsadraee, M., Sankian, M.et al. (2009) Is serum or sputum eosinophil cationic protein level adequate for diagnosis of mild asthma?. Iranian Journal of Allergy, Asthma and Immunology8(3): 155–160 [PubMed: 20124607]

- Population not relevant to this review protocol

Average age >17 years

Khan, M.R., Ali, F., Batool, S.et al. (2022) Association between Raised Serum IgE Levels and Bronchial Asthma in Children. Pakistan Journal of Medical and Health Sciences16(4): 594–595

- Study design not relevant to this review protocol

No reference standard used

Korevaar, D.A., Westerhof, G.A., Wang, J.et al. (2015) Diagnostic accuracy of minimally invasive markers for detection of airway eosinophilia in asthma: A systematic review and meta-analysis. The Lancet Respiratory Medicine3(4): 290–300 [PubMed: 25801413]- Systematic review used as source of primary studiesKorppi, Matti, Hyvarinen, Mari, Kotaniemi-Syrjanen, Anneet al. (2008) Early exposure and sensitization to cat and dog: different effects on asthma risk after wheezing in infancy. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology19(8): 696–701 [PubMed: 19076565]

- Population not relevant to this review protocol

Average age <5 years

Kovac, Kornelija, Dodig, Slavica, Tjesic-Drinkovic, Dorijanet al. (2007) Correlation between asthma severity and serum IgE in asthmatic children sensitized to Dermatophagoides pteronyssinus. Archives of medical research38(1): 99–105 [PubMed: 17174732]

- Population not relevant to this review protocol

Already diagnosed with asthma

Lee, Youn Kyung, Yang, Sohyoung, Park, Joohyunet al. (2015) House dust mite-specific immunoglobulin E and longitudinal exhaled nitric oxide measurements in children with atopic asthma. Korean journal of pediatrics58(3): 89–95 [PMC free article: PMC4388976] [PubMed: 25861331]

- Population not relevant to this review protocol

Already diagnosed with asthma

Maloney, Jennifer M, Rudengren, Magnus, Ahlstedt, Staffanet al. (2008) The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy. The Journal of allergy and clinical immunology122(1): 145–51 [PubMed: 18502490]

- Condition not relevant to this review protocol

Study aiming to diagnose allergy to nuts

Moverare, Robert, Persson, Eilif, Malinovschi, Andreiet al. (2023) Reference values of serum total IgE in Uppsala - comparison over four decades. Upsala journal of medical sciences128 [PMC free article: PMC10710850] [PubMed: 38084204]

- Population not relevant to this review protocol

Retrospective analyses of biobank samples in people that did not necessarily have symptoms of asthma

Muthu, V., Singh, P., Choudhary, H.et al. (2020) Diagnostic Cutoffs and Clinical Utility of Recombinant Aspergillus fumigatus Antigens in the Diagnosis of Allergic Bronchopulmonary Aspergillosis. Journal of Allergy and Clinical Immunology: In Practice8(2): 579–587 [PubMed: 31520840]

- Population not relevant to this review protocol

Already diagnosed with respiratory condition

Ott, H., Stanzel, S., Ocklenburg, C.et al. (2009) Total serum IgE as a parameter to differentiate between intrinsic and extrinsic atopic dermatitis in children. Acta Dermato-Venereologica89(3): 257–261 [PubMed: 19479121]

- Population not relevant to this review protocol

Average age <5 years

Paganelli, R, Ansotegui, I J, Sastre, Jet al. (1998) Specific IgE antibodies in the diagnosis of atopic disease. Clinical evaluation of a new in vitro test system, UniCAP, in six European allergy clinics. Allergy53(8): 763–8 [PubMed: 9722225]

- Population not relevant to this review protocol

Inclusion criteria 8-81 years, average not reported

Passalacqua, G, Melioli, G, Bonifazi, Fet al. (2013) The additional values of microarray allergen assay in the management of polysensitized patients with respiratory allergy. Allergy68(8): 1029–33 [PubMed: 23889678]

- Population not relevant to this review protocol

Average age >16 years

Perzanowski, Matthew S, Ng’ang’a, Lucy W, Carter, Melody Cet al. (2002) Atopy, asthma, and antibodies to Ascaris among rural and urban children in Kenya. The Journal of pediatrics140(5): 582–8 [PubMed: 12032526]

- Population not relevant to this review protocol

Not presenting with respiratory symptoms

Pescollderungg, L., Peroni, D., Locatelli, F.et al. (2000) Determination of serum eosinophil cationic protein, eosinophil count, and total IgE in children with different severities of atopic diseases. Pediatric Asthma, Allergy and Immunology14(2): 109–118

- Study design not relevant to this review protocol

Assessing correlations between diagnostic tests

Peveri, S, Pattini, S, Costantino, M Tet al. (2019) Molecular diagnostics improves diagnosis and treatment of respiratory allergy and food allergy with economic optimization and cost saving. Allergologia et immunopathologia47(1): 64–72 [PubMed: 30245286]

- Study design not relevant to this review protocol

No reference standard in study

Pourpak, Z, Mozaffari, H, Gharagozlou, Met al. (2008) Asthma in patients with atopic dermatitis. Indian journal of pediatrics75(2): 139–41 [PubMed: 18334794]

- Population not relevant to this review protocol

Not presenting with respiratory symptoms

Redding, Gregory J, Singleton, Rosalyn J, DeMain, Jeffreyet al. (2006) Relationship between IgE and specific aeroallergen sensitivity in Alaskan native children. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology97(2): 209–15 [PubMed: 16937753]

- Population not relevant to this review protocol

Not presenting with respiratory symptoms

Saf, S., Sifers, T.M., Baker, M.G.et al. (2020) Diagnosis of Sesame Allergy: Analysis of Current Practice and Exploration of Sesame Component Ses i 1. Journal of Allergy and Clinical Immunology: In Practice8(5): 1681–1688e3 [PubMed: 31786253]- Full text paper not availableSaito, Junpei, Inoue, Keiichi, Sugawara, Ayaet al. (2004) Exhaled nitric oxide as a marker of airway inflammation for an epidemiologic study in schoolchildren. The Journal of allergy and clinical immunology114(3): 512–6 [PubMed: 15356549]

- Population not relevant to this review protocol

Not presenting with respiratory symptoms

Salehi, Tahmineh, Pourpak, Zahra, Karkon, Shahnazet al. (2009) The study of egg allergy in children with atopic dermatitis. The World Allergy Organization journal2(7): 123–7 [PMC free article: PMC3650957] [PubMed: 23283060]

- Population not relevant to this review protocol

Average age <5 years

Samolinski, B., Namyslowski, A., Raciborski, F.et al. (2016) The importance of specific IgE in epidemiology of allergic rhinitis and asthma - survey Epidemiology of Allergic Diseases in Poland (ECAP). Alergologia Polska - Polish Journal of Allergology3(3): 102–107- Study not reported in EnglishSantoso, H (1998) The value of a single skin prick testing for specific IgE Dermatophagoides pteronyssinus to distinguish atopy from non-atopic asthmatic children in the tropics. Asian Pacific journal of allergy and immunology16(23): 69–74 [PubMed: 9876943]

- Population not relevant to this review protocol

Participants were already diagnosed with asthma prior to study entry - study aimed to distinguish between atopic and non-atopic asthma

Schulze, J., Reinmuller, W., Herrmann, E.et al. (2013) Bronchial allergen challenges in children - safety and predictors. Pediatric Allergy and Immunology24(1): 19–27 [PubMed: 23331526]

- Population not relevant to this review protocol

Already diagnosed with asthma

Severcan, E.U., Bal, C.M., Gulen, F.et al. (2022) Identifying wheezing phenotypes in a pediatric Turkish cohort. Journal of Asthma59(7): 1298–1304 [PubMed: 33906564]

- Study design not relevant to this review protocol

Longitudinal study examining prognostic factors for wheezing

Shaikh, W.A. and Shaikh, S.W. (2006) Skin prick test - More reliable than estimation of specific IgE in allergy diagnosis. Journal of the Indian Medical Association104(10): 592–595 [PubMed: 17380826]

- Population not relevant to this review protocol

Average age >16 years

Shibata, R., Fujiogi, M., Nanishi, M.et al. (2022) Total immunoglobulin E in infant bronchiolitis and risk of developing asthma. Journal of Allergy and Clinical Immunology: In Practice10(10): 2761–2763e2 [PubMed: 35803539]

- Study design not relevant to this review protocol

Prospective study of factors predicting development of asthma

Soriano, J.B., Anto, J.M., Sunyer, J.et al. (1999) Risk of asthma in the general Spanish population attributable to specific immunoresponse. International Journal of Epidemiology28(4): 728–734 [PubMed: 10480703]

- Population not relevant to this review protocol

Not presenting with respiratory symptoms

Tang, R B; Wu, K G; Hwang, B (1994) Comparison between skin testing and in vitro testing for diagnosis of allergen in asthmatic children. Zhonghua yi xue za zhi = Chinese medical journal; Free China ed54(4): 246–50 [PubMed: 7982135]- Full text paper not availableTee, R D, Cullinan, P, Welch, Jet al. (1998) Specific IgE to isocyanates: a useful diagnostic role in occupational asthma. The Journal of allergy and clinical immunology101(5): 709–15 [PubMed: 9600510]

- Population not relevant to this review protocol

Average age >16 years

Valovirta, E, Jacobsen, L, Ljorring, Cet al. (2006) Clinical efficacy and safety of sublingual immunotherapy with tree pollen extract in children. Allergy61(10): 1177–83 [PubMed: 16942565]

- Study design not relevant to this review protocol

Intervention study

Vermani, M.; Vijayan, V.K.; Agarwal, M.K. (2015) Identification of Aspergillus (A flavus and A niger) allergens and heterogeneity of allergic patients’ IgE response. Iranian Journal of Allergy, Asthma and Immunology14(4): 361–369 [PubMed: 26547703]

- Population not relevant to this review protocol

Already diagnosed with respiratory condition

Visitsunthorn, N., Sripramong, C., Bunnag, C.et al. (2017) Comparison between specific IgE levels and skin prick test results of local and imported American cockroach, dog, cat, dust mites and mold allergen extracts. Asian Pacific Journal of Allergy and Immunology35(1): 60–65 [PubMed: 27362401]

- Population not relevant to this review protocol

Average age >17 years

Weinmayr, G, Genuneit, J, Nagel, Get al. (2010) International variations in associations of allergic markers and diseases in children: ISAAC Phase Two. Allergy65(6): 766–75 [PubMed: 20028376]

- Population not relevant to this review protocol

Not presenting with respiratory symptoms

Welsh, Kathryn G, Holden, Karl A, Wardlaw, Andrew Jet al. (2021) Fungal sensitization and positive fungal culture from sputum in children with asthma are associated with reduced lung function and acute asthma attacks respectively. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology51(6): 790–800 [PubMed: 33274520]

- Population not relevant to this review protocol

Already diagnosed with asthma

Wenting, L., Baoqing, S., Nili, W.et al. (2014) Distribution and component analysis of 51 allergens among patients with allergic diseases in Guangzhou, Southern China. Allergy: European Journal of Allergy and Clinical Immunology69(suppl99): 303- Conference abstractYalcin, A.D., Bisgin, A., Kargi, A.et al. (2012) Serum-soluble TRAIL levels in patients with severe persistent allergic asthma: Its relation to omalizumab treatment. Medical Science Monitor18(3): pl11–pl15 [PMC free article: PMC3560751] [PubMed: 22367138]

- Population not relevant to this review protocol

Average age >17 years

Yan, Junmei, Chen, Jing, Li, Haiqiet al. (2018) The comparison of skin prick test, serological specific IgE test and solid phase immunoassay in the diagnosis of infantile allergic diseases. Minerva pediatrica [PubMed: 30037186]- Full text paper not availableZahoor, F., ur Rehman, F., Shahnawaz, K.et al. (2019) Role of serum CRP, IgE, and complement levels in pediatric population. Medical Forum Monthly30(8): 27–30

- Population not relevant to this review protocol

Already diagnosed with asthma

Zhang, L; Prietsch, SOM; Ducharme, FM (2014) Inhaled corticosteroids in children with persistent asthma: effects on growth. Cochrane Database of Systematic Reviews [PMC free article: PMC8407362] [PubMed: 25030198]

- Study design not relevant to this review protocol

Not a diagnostic accuracy study

Evidence reviews for diagnostic test accuracy of IgE in children (2025)

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